Astragalus Extract Mixture(HT042): Children’s height growth

Ingredient Name	Astragalus Extract Mixture(HT042)
Approval No.	Individual Recognition No. 2014-40
Health Claim	This is an individually recognized ingredient that may help children’s height growth.
Intake Amount	1,500 mg/day
Materials	Astragalus, Eleutherococcus senticosus, Phlomis Umbrosa
Features	- HT042 is the first and only ingredient that is approved by the MFDS for children’s height growth. - It achieved the third place of production performance among every individually recognized health functional food ingredients in the first year of product launch. - It is the only functional ingredient that confirmed significant height growth subjected to children. - Significant height growth efficacy was confirmed in 24-week intake clinical trial compared to the control group. - According to the OECD guideline assessment, there was no sex hormone-like effect, which is the cause of precocious puberty. - There was no toxicity observed even with 13 times the daily intake amount. - The height growth of phlomis umbrosa, a component of HT042, was also internationally approved. - Only ingredients that are certified as phlomis umbrosa by the MFDS differentiation criteria are used. - 1 domestic patent registered - 10 SCI papers published
Scientific Evidence	- Significant height growth compared to the control group¹ - Height SDS significantly increased compared to the control group¹ - Chondrocyte in growth plate was proliferated² - Thickness of growth plate was increased² - Growth rate of bone length was increased² - IGF-1, IGFBP-3, and BMP-2 expression was increased²˜³ - No sex hormone-like effect was found³