Astragalus extract mixture (children’s height growth)

Name	Astragalus extract mixture
No.	2014-40
Health Claim	Help growth of children’s height
Dose	1,500mg/ day
Contents	Astragalus membranaceus, Eleutherococcus senticosus, Phlomis umbrosa
Features	- Approved the first and only height growth functional food by MFDS (Korean FDA) - Achieved 3rd place in manufacturing scale of individually approved ingredients. - Researched height growth effect significantly in RCT for children. - Observed height growth function in 24-week RCT. - Have NO estrogen-like effect caused precocious puberty in animal test by OECD guideline. - Have NO toxicity in 13 times higher doses. - Height growth effect of P. umbrosa, the contents of HT042, was published in SCI journal. - P. umbrosa was identified via MFDS guideline. - 1 patent was registered. - 4 papers were published
Function	- Height growth was increased significantly compared to control group¹ - Height SDS was increased significantly compared to control group¹ - Chondrocyte in growth plate was proliferated² - Thickness of growth plate was increased² - Growth velocity of bone length was increased² - IGF-1, IGFBP-3, BMP-2 expression was increased²˜³ - No estrogen like effect³